2026-04-09T16:13:12Z https://www.fdr.uni-hamburg.de/oai2d

oai:fdr.uni-hamburg.de:13168 2023-08-23T14:10:43Z user-uhh user-cogpsy

Hendrik Heinbockel Lars Schwabe Anthony D Wagner 2023-08-16 Stress after retrieval can impair future remembering. These memory impairments may be attributed to a weakening of the original memory during reactivation-dependent reconsolidation or to the creation of competitive memory traces that can interfere with future retrieval. Although reconsolidation and interference theories predict forgetting, the neural mechanisms underlying potentially disruptive effects of post-retrieval stress on future remembering are completely unknown. Here, we used a three-day paradigm in which participants underwent functional MRI scanning during initial encoding of word-picture pairs (Day1), partial reactivation of these pairs shortly before a stress or control manipulation (Day 2), and a final cued-recall test (Day 3). Our results show that post-reactivation stress impairs subsequent memory depending on the strength of neural reinstatement of the memory trace during reactivation, as reflected in category-level reinstatement in ventrotemporal cortex (VTC), trial-wise hippocampal encoding-retrieval similarity and the connectivity of the hippocampus with the posterior cingulate cortex (PCC). Moreover, comparison of Day1 to Day3 memory representations in the PCC revealed that successful Day 3 recall was linked to Day1-Day3 pattern dissimilarity in controls, suggesting the use of a different trace, whereas stressed participants relied on the original memory representation. These neural representation changes were again dependent on VTC reinstatement during reactivation. Together, our findings suggest that the impairing effects of post-retrieval stress on future memory relate to the strength of reactivation of the original memory trace, driven by the hippocampus and its crosstalk with neocortical representation areas, revealing disruptive effects on the formation of multiple memory traces. https://www.fdr.uni-hamburg.de/record/13168 10.25592/uhhfdm.13168 oai:fdr.uni-hamburg.de:13168 eng doi:10.25592/uhhfdm.13167 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Stress, reconsolidation, episodic memory, hippocampus Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:13164 2023-08-17T21:13:55Z user-cogpsy user-uhh

Anna-Maria Grob Hendrik Heinbockel Branka Milivojevic Christian Doeller Lars Schwabe 2023-08-14 Maintaining an accurate model of the world relies on our ability to update memory representations in light of new information. Previous research on the integration of new information into memory mainly focused on the hippocampus. Here, we hypothesized that the angular gyrus, known to be involved in episodic memory and imagination, plays a pivotal role in the insight-driven reconfiguration of memory representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) inhibiting the left angular gyrus or sham stimulation before gaining insight into the relationship between previously separate life-like animated events in a narrative-insight task. During this task, participants also underwent EEG recording and their memory for linked and non-linked events was assessed shortly thereafter. Our results show that cTBS to the angular gyrus decreased memory for the linking events and reduced the memory advantage for linked relative to non-linked events. At the neural level, cTBS-induced angular gyrus inhibition reduced centro-temporal coupling with frontal regions and abolished insight-induced neural representational changes for events linked via imagination, indicating impaired memory reconfiguration. Further, the cTBS group showed representational changes for non-linked events that resembled the patterns observed in the sham group for the linked events, suggesting failed pruning of the narrative in memory. Together, our findings demonstrate a causal role of the left angular gyrus in insight-related memory reconfigurations. https://www.fdr.uni-hamburg.de/record/13164 10.25592/uhhfdm.13164 oai:fdr.uni-hamburg.de:13164 doi:10.25592/uhhfdm.13163 info:eu-repo/semantics/restrictedAccess Causal role of the angular gyrus in insight-driven memory reconfiguration - restricted info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:14163 2024-10-02T13:47:36Z user-uhh user-cogpsy

Kaja Loock Felix Kalbe Lars Schwabe 2024-02-28 While prediction errors (PEs) have long been recognized as critical in associative learning, emerging evidence indicates their significant role in episodic memory formation. This series of four experiments sought to elucidate the cognitive mechanisms underlying the enhancing effects of PEs related to aversive events on memory for surrounding neutral events. Specifically, we aimed to determine whether these PE effects are specific to predictive stimuli preceding the PE or if PEs create a transient window of enhanced, unselective memory formation. In a combined incidental encoding-fear learning task, participants (n=xxx) estimated aversive shock probabilities after unique stimuli. Physiological arousal and explicit PEs were measured during encoding to predict recognition memory tested either immediately after encoding (Experiment 3) or 24 hours later (Experiments 1-4). Our results show that PE-driven memory enhancement extends beyond predictive stimuli preceding the PE event to those encountered afterward. Furthermore, the retroactive memory enhancement induced by PEs may extend back longer than previously assumed, impacting stimuli presented 10 seconds before the PE. Importantly, our findings reveal that PE-related memory enhancement is specific to predictive stimuli, with uninformative stimuli not benefiting from PEs and even interfering with the PE-driven memory enhancement. This pattern demonstrates that PE effects are not unspecific but that PEs enhance memory for predictive stimuli encountered around a PE event. Notably, memory-enhancing effects of PEs persist even when controlling for changes in arousal. These findings provide insights into the cognitive mechanisms of PE-induced enhancements of memory, with potential implications for understanding aberrant emotional memory in fear-related disorders. https://www.fdr.uni-hamburg.de/record/14163 10.25592/uhhfdm.14163 oai:fdr.uni-hamburg.de:14163 doi:10.25592/uhhfdm.14146 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode episodic memory, aversive learning, prediction error, arousal Cognitive mechanisms of aversive prediction error-induced memory enhancements info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:12884 2023-07-18T08:11:30Z user-cogpsy user-uhh

Heinbockel, Hendrik Quaedflieg, Conny W.E.M. Schneider, Till Engel, Andreas K. Schwabe, Lars 2021-11-15 Data is stored on the FDR solely as backup/archive. Stressful events impact memory formation, in particular for emotionally arousing stimuli. Although these stress effects on emotional memory formation have potentially far-reaching implications, the underlying neural mechanisms are not fully understood. Specifically, the temporal processing dimension of the mechanisms involved in emotional memory formation under stress remains elusive. Here, we used magnetoencephalography (MEG) to examine the neural processes underlying stress effects on emotional memory formation with high temporal and spatial resolution and a particular focus on theta oscillations previously implicated in mnemonic binding. Healthy participants (n = 53) underwent a stress or control procedure before encoding emotionally neutral and negative pictures, while MEG was recorded. Memory for the pictures was probed in a recognition test 24 h after encoding. In this recognition test, stress did not modulate the emotional memory enhancement but led to significantly higher confidence in memory for negative compared to neutral stimuli. Our neural data revealed that stress increased memory-related theta oscillations specifically in medial temporal and occipito-parietal regions. Further, this stress-related increase in theta power emerged during memory formation for emotionally negative but not for neutral stimuli. These findings indicate that acute stress can enhance, in the medial temporal lobe, oscillations at a frequency that is ideally suited to bind the elements of an ongoing emotional episode, which may represent a mechanism to facilitate the storage of emotionally salient events that occurred in the context of a stressful encounter. https://www.fdr.uni-hamburg.de/record/12884 10.1016/j.ynstr.2021.100383 oai:fdr.uni-hamburg.de:12884 info:eu-repo/semantics/closedAccess Stress, Memory formation, Emotional memory, MEG, Medial temporal lobe Stress enhances emotional memory-related theta oscillations in the medial temporal lobe info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:13187 2023-08-23T14:10:43Z user-cogpsy user-uhh

Hendrik Heinbockel Lars Schwabe Anthony D Wagner 2023-08-16 Stress after retrieval can impair future remembering. These memory impairments may be attributed to a weakening of the original memory during reactivation-dependent reconsolidation or to the creation of competitive memory traces that can interfere with future retrieval. Although reconsolidation and interference theories predict forgetting, the neural mechanisms underlying potentially disruptive effects of post-retrieval stress on future remembering are completely unknown. Here, we used a three-day paradigm in which participants underwent functional MRI scanning during initial encoding of word-picture pairs (Day1), partial reactivation of these pairs shortly before a stress or control manipulation (Day 2), and a final cued-recall test (Day 3). Our results show that post-reactivation stress impairs subsequent memory depending on the strength of neural reinstatement of the memory trace during reactivation, as reflected in category-level reinstatement in ventrotemporal cortex (VTC), trial-wise hippocampal encoding-retrieval similarity and the connectivity of the hippocampus with the posterior cingulate cortex (PCC). Moreover, comparison of Day1 to Day3 memory representations in the PCC revealed that successful Day 3 recall was linked to Day1-Day3 pattern dissimilarity in controls, suggesting the use of a different trace, whereas stressed participants relied on the original memory representation. These neural representation changes were again dependent on VTC reinstatement during reactivation. Together, our findings suggest that the impairing effects of post-retrieval stress on future memory relate to the strength of reactivation of the original memory trace, driven by the hippocampus and its crosstalk with neocortical representation areas, revealing disruptive effects on the formation of multiple memory traces. https://www.fdr.uni-hamburg.de/record/13187 10.25592/uhhfdm.13187 oai:fdr.uni-hamburg.de:13187 eng doi:10.25592/uhhfdm.13167 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Stress, reconsolidation, episodic memory, hippocampus Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:13179 2023-08-31T07:38:46Z user-uhh user-cogpsy

Heinbockel, Hendrik Schwabe, Lars 2023-08-30 Raw dicom files as well as native space structral and functional MRI images. Data was not defaced or normalized and to protect the privacy of our participants we will hand out this data only on request, https://www.fdr.uni-hamburg.de/record/13179 10.25592/uhhfdm.13179 oai:fdr.uni-hamburg.de:13179 doi:10.25592/uhhfdm.13178 info:eu-repo/semantics/restrictedAccess [Raw MRI data, not defaced] Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:12928 2023-07-23T19:53:48Z user-cogpsy user-uhh

Anna-Maria Grob Hendrik Heinbockel Branka Milivojevic Christian Doeller Lars Schwabe 2023-07-18 Maintaining an accurate model of the world relies on our ability to update memory representations in light of new information. Previous research on the integration of new information into memory mainly focused on the hippocampus. Here, we hypothesized that the angular gyrus, known to be involved in episodic memory and imagination, plays a pivotal role in the insight-driven reconfiguration of memory representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) inhibiting the left angular gyrus or sham stimulation before gaining insight into the relationship between previously separate life-like animated events in a narrative-insight task. During this task, participants also underwent EEG recording and their memory for linked and non-linked events was assessed shortly thereafter. Our results show that cTBS to the angular gyrus decreased memory for the linking events and reduced the memory advantage for linked relative to non-linked events. At the neural level, cTBS-induced angular gyrus inhibition reduced centro-temporal coupling with frontal regions and abolished insight-induced neural representational changes for events linked via imagination, indicating impaired memory reconfiguration. Further, the cTBS group showed representational changes for non-linked events that resembled the patterns observed in the sham group for the linked events, suggesting failed pruning of the narrative in memory. Together, our findings demonstrate a causal role of the left angular gyrus in insight-related memory reconfigurations. https://www.fdr.uni-hamburg.de/record/12928 10.25592/uhhfdm.12928 oai:fdr.uni-hamburg.de:12928 doi:10.25592/uhhfdm.12927 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Causal role of the angular gyrus in insight-driven memory reconfiguration info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:14147 2024-03-06T14:36:57Z user-uhh user-cogpsy

Kaja Loock Felix Kalbe Lars Schwabe 2024-02-28 While prediction errors (PEs) have long been recognized as critical in associative learning, emerging evidence indicates their significant role in episodic memory formation. This series of four experiments sought to elucidate the cognitive mechanisms underlying the enhancing effects of PEs related to aversive events on memory for surrounding neutral events. Specifically, we aimed to determine whether these PE effects are specific to predictive stimuli preceding the PE or if PEs create a transient window of enhanced, unselective memory formation. In a combined incidental encoding-fear learning task, participants (n=xxx) estimated aversive shock probabilities after unique stimuli. Physiological arousal and explicit PEs were measured during encoding to predict recognition memory tested either immediately after encoding (Experiment 3) or 24 hours later (Experiments 1-4). Our results show that PE-driven memory enhancement extends beyond predictive stimuli preceding the PE event to those encountered afterward. Furthermore, the retroactive memory enhancement induced by PEs may extend back longer than previously assumed, impacting stimuli presented 10 seconds before the PE. Importantly, our findings reveal that PE-related memory enhancement is specific to predictive stimuli, with uninformative stimuli not benefiting from PEs and even interfering with the PE-driven memory enhancement. This pattern demonstrates that PE effects are not unspecific but that PEs enhance memory for predictive stimuli encountered around a PE event. Notably, memory-enhancing effects of PEs persist even when controlling for changes in arousal. These findings provide insights into the cognitive mechanisms of PE-induced enhancements of memory, with potential implications for understanding aberrant emotional memory in fear-related disorders. https://www.fdr.uni-hamburg.de/record/14147 10.25592/uhhfdm.14147 oai:fdr.uni-hamburg.de:14147 doi:10.25592/uhhfdm.14146 info:eu-repo/semantics/restrictedAccess episodic memory, aversive learning, prediction error, arousal Cognitive mechanisms of aversive prediction error-induced memory enhancements info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:17815 2026-01-30T12:16:03Z user-cogpsy user-uhh

Hendrik Heinbockel Aidan J. Horner Lars Schwabe 2025-08-13 Reactivation of encoding-related neural patterns during retrieval—known as encoding–pattern reinstatement (EPR)—is thought to support episodic memory. Yet, direct evidence for its functional relevance remains limited, and it is unclear whether such content-specific reinstatement can be systematically modulated. Here, we show that non-invasive stimulation of category-selective cortex enhances both memory performance and underlying neural reinstatement in a content-specific manner. Participants encoded word–face and word–scene pairs on Day 1 and received intermittent theta burst stimulation (iTBS) or sham stimulation to the right occipital face area prior to retrieval on Day 2. ITBS selectively improved memory for faces but not scenes. EEG multivariate pattern analysis revealed stronger reinstatement of encoding patterns for faces in the stimulation group. These findings suggest that category-selective cortical regions contribute to content-specific reinstatement during memory retrieval, and that modulating this mechanism may offer new leverage points for targeting representational deficits in memory-related disorders. https://www.fdr.uni-hamburg.de/record/17815 10.25592/uhhfdm.17815 oai:fdr.uni-hamburg.de:17815 doi:10.25592/uhhfdm.17814 info:eu-repo/semantics/restrictedAccess Targeted stimulation of a category-selective visual region at retrieval boosts memory via enhancing category-specific reinstatement info:eu-repo/semantics/other dataset

oai:fdr.uni-hamburg.de:18260 2026-01-30T12:16:03Z user-cogpsy user-uhh

Hendrik Heinbockel Aidan J. Horner Lars Schwabe 2025-08-13 Reactivation of encoding-related neural patterns during retrieval—known as encoding–pattern reinstatement (EPR)—is thought to support episodic memory. Yet, direct evidence for its functional relevance remains limited, and it is unclear whether such content-specific reinstatement can be systematically modulated. Here, we show that non-invasive stimulation of category-selective cortex enhances both memory performance and underlying neural reinstatement in a content-specific manner. Participants encoded word–face and word–scene pairs on Day 1 and received intermittent theta burst stimulation (iTBS) or sham stimulation to the right occipital face area prior to retrieval on Day 2. ITBS selectively improved memory for faces but not scenes. EEG multivariate pattern analysis revealed stronger reinstatement of encoding patterns for faces in the stimulation group. These findings suggest that category-selective cortical regions contribute to content-specific reinstatement during memory retrieval, and that modulating this mechanism may offer new leverage points for targeting representational deficits in memory-related disorders. https://www.fdr.uni-hamburg.de/record/18260 10.25592/uhhfdm.18260 oai:fdr.uni-hamburg.de:18260 doi:10.25592/uhhfdm.17814 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Targeted stimulation of a category-selective visual region at retrieval boosts memory via enhancing category-specific reinstatement info:eu-repo/semantics/other dataset