April 15, 2021 Dataset Open Access

Puelles, Victor; Solagna, Francesca; Wanner, Nicola; Zhao, Yu

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{"conceptdoi":"10.25592/uhhfdm.8996","conceptrecid":"8996","created":"2021-04-15T13:32:24.594547+00:00","doi":"10.25592/uhhfdm.8997","id":8997,"links":{"badge":"https://www.fdr.uni-hamburg.de/badge/doi/10.25592/uhhfdm.8997.svg","conceptbadge":"https://www.fdr.uni-hamburg.de/badge/doi/10.25592/uhhfdm.8996.svg","conceptdoi":"http://doi.org/10.25592/uhhfdm.8996","doi":"http://doi.org/10.25592/uhhfdm.8997"},"metadata":{"access_right":"open","access_right_category":"success","communities":[{"id":"uhh"}],"creators":[{"affiliation":"III. MED, UKE Hamburg-Eppendorf","name":"Puelles, Victor","orcid":"0000-0002-7735-5462"},{"affiliation":"III. MED, UKE Hamburg-Eppendorf","name":"Solagna, Francesca","orcid":"0000-0001-6607-2291"},{"affiliation":"III. MED, UKE Hamburg-Eppendorf","name":"Wanner, Nicola","orcid":"0000-0002-4886-7020"},{"affiliation":"ZMNH, UKE Hamburg.Eppendorf","name":"Zhao, Yu"}],"description":"<p>Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan approach to investigate skeletal muscle wasting in CKD. We identified an increased production and elevated blood levels of soluble pro-cachectic factor Activin A, directly linking experimental and human CKD to skeletal muscle wasting programs. Single cell sequencing data identified the expression of Activin A in specific kidney cell populations, namely a subpopulation of fibroblasts and cells of the juxtaglomerular apparatus. Based on our findings, we propose that persistent and increased kidney production of pro-cachectic factors combined with a lack of kidney clearance facilitate a vicious signalling kidney-muscle cycle, leading to exacerbated blood accumulation of Activin A, and thereby skeletal muscle wasting in CKD.</p>","doi":"10.25592/uhhfdm.8997","keywords":["scRNA-seq, kidney, muscle, Kif3aKSPCre mice"],"license":{"id":"CC-BY-4.0"},"notes":"We performed single-cell RNA sequencing on 5-week-old Kif3a\u0394Tub and control kidneys.","publication_date":"2021-04-15","related_identifiers":[{"identifier":"10.25592/uhhfdm.8996","relation":"isVersionOf","scheme":"doi"}],"relations":{"version":[{"count":1,"index":0,"is_last":true,"last_child":{"pid_type":"recid","pid_value":"8997"},"parent":{"pid_type":"recid","pid_value":"8996"}}]},"resource_type":{"title":"Dataset","type":"dataset"},"title":"Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs"},"owners":[148],"revision":2,"updated":"2021-05-20T21:25:19.225976+00:00"}