December 1, 2020 Dataset Open Access

Wanner, Nicola; Andrieux, Geoffroy; Puelles, Victor G

DataCite XML Export

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-3" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
  <identifier identifierType="DOI">10.25592/uhhfdm.8358</identifier>
  <creators>
    <creator>
      <creatorName>Wanner, Nicola</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-4886-7020</nameIdentifier>
      <affiliation>III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Andrieux, Geoffroy</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-5389-9481</nameIdentifier>
      <affiliation>Institute of Medical Bioinformatics and Systems Medicine, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Puelles, Victor G</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7735-5462</nameIdentifier>
      <affiliation>III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Molecular consequences of SARS-CoV-2 liver tropism</title>
  </titles>
  <publisher>Universität Hamburg</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>COVID-19</subject>
    <subject>SARS-CoV-2</subject>
    <subject>liver</subject>
    <subject>transcriptome</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-12-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Dataset"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://www.fdr.uni-hamburg.de/record/8358</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsPartOf">10.25592/uhhfdm.8357</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidney and liver. Previous studies have shown that close to 20% of hospitalized patients with COVID-19 develop liver injury, showing an association to disease severity. Here, we characterized SARS-CoV-2 liver tropism in autopsy samples, based on the expression of cell-entry facilitators in parenchymal cells, clinical polymerase chain reaction (PCR) positivity, subgenomic SARS-CoV-2 identification using RNA sequencing, and viral RNA detection by in situ hybridization. Next, we unraveled the transcriptomic&amp;nbsp; landscape of SARS-CoV-2 liver tropism, revealing significant increases in interferon alpha and gamma signaling and compensatory liver-specific metabolic regulation. While these results reflect changes in tissues from patients with severe SARS-CoV-2 infection, the profound molecular alterations raise questions about the potential long-term consequences of COVID-19 infection. &amp;nbsp;&amp;nbsp;&lt;/p&gt;</description>
  </descriptions>
</resource>