December 1, 2020 Dataset Open Access

Wanner, Nicola; Andrieux, Geoffroy; Puelles, Victor G

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{"@context":"https://schema.org/","@id":"http://doi.org/10.25592/uhhfdm.8358","@type":"Dataset","creator":[{"@id":"https://orcid.org/0000-0002-4886-7020","@type":"Person","affiliation":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany","name":"Wanner, Nicola"},{"@id":"https://orcid.org/0000-0002-5389-9481","@type":"Person","affiliation":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany","name":"Andrieux, Geoffroy"},{"@id":"https://orcid.org/0000-0002-7735-5462","@type":"Person","affiliation":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany","name":"Puelles, Victor G"}],"datePublished":"2020-12-01","description":"<p>Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidney and liver. Previous studies have shown that close to 20% of hospitalized patients with COVID-19 develop liver injury, showing an association to disease severity. Here, we characterized SARS-CoV-2 liver tropism in autopsy samples, based on the expression of cell-entry facilitators in parenchymal cells, clinical polymerase chain reaction (PCR) positivity, subgenomic SARS-CoV-2 identification using RNA sequencing, and viral RNA detection by in situ hybridization. Next, we unraveled the transcriptomic&nbsp; landscape of SARS-CoV-2 liver tropism, revealing significant increases in interferon alpha and gamma signaling and compensatory liver-specific metabolic regulation. While these results reflect changes in tissues from patients with severe SARS-CoV-2 infection, the profound molecular alterations raise questions about the potential long-term consequences of COVID-19 infection. &nbsp;&nbsp;</p>","distribution":[{"@type":"DataDownload","contentUrl":"https://www.fdr.uni-hamburg.de/api/files/0ccdfee9-2f09-4e1e-a6f2-9860b4a76be2/logCPM.txt","encodingFormat":"txt"},{"@type":"DataDownload","contentUrl":"https://www.fdr.uni-hamburg.de/api/files/0ccdfee9-2f09-4e1e-a6f2-9860b4a76be2/logTPM.txt","encodingFormat":"txt"},{"@type":"DataDownload","contentUrl":"https://www.fdr.uni-hamburg.de/api/files/0ccdfee9-2f09-4e1e-a6f2-9860b4a76be2/SupplT2_limma covid_liver_POS-covid_liver_NEG.xlsx","encodingFormat":"xlsx"},{"@type":"DataDownload","contentUrl":"https://www.fdr.uni-hamburg.de/api/files/0ccdfee9-2f09-4e1e-a6f2-9860b4a76be2/SupplT3_GAGE_covid_liver_POS-covid_liver_NEG_H.xlsx","encodingFormat":"xlsx"}],"identifier":"http://doi.org/10.25592/uhhfdm.8358","keywords":["COVID-19","SARS-CoV-2","liver","transcriptome"],"license":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Molecular consequences of SARS-CoV-2 liver tropism","url":"https://www.fdr.uni-hamburg.de/record/8358"}