December 1, 2020 Dataset Open Access

Wanner, Nicola; Andrieux, Geoffroy; Puelles, Victor G

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Wanner, Nicola</dc:creator>
  <dc:creator>Andrieux, Geoffroy</dc:creator>
  <dc:creator>Puelles, Victor G</dc:creator>
  <dc:date>2020-12-01</dc:date>
  <dc:description>Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidney and liver. Previous studies have shown that close to 20% of hospitalized patients with COVID-19 develop liver injury, showing an association to disease severity. Here, we characterized SARS-CoV-2 liver tropism in autopsy samples, based on the expression of cell-entry facilitators in parenchymal cells, clinical polymerase chain reaction (PCR) positivity, subgenomic SARS-CoV-2 identification using RNA sequencing, and viral RNA detection by in situ hybridization. Next, we unraveled the transcriptomic  landscape of SARS-CoV-2 liver tropism, revealing significant increases in interferon alpha and gamma signaling and compensatory liver-specific metabolic regulation. While these results reflect changes in tissues from patients with severe SARS-CoV-2 infection, the profound molecular alterations raise questions about the potential long-term consequences of COVID-19 infection.   </dc:description>
  <dc:identifier>https://www.fdr.uni-hamburg.de/record/8358</dc:identifier>
  <dc:identifier>10.25592/uhhfdm.8358</dc:identifier>
  <dc:identifier>oai:fdr.uni-hamburg.de:8358</dc:identifier>
  <dc:relation>doi:10.25592/uhhfdm.8357</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:subject>COVID-19</dc:subject>
  <dc:subject>SARS-CoV-2</dc:subject>
  <dc:subject>liver</dc:subject>
  <dc:subject>transcriptome</dc:subject>
  <dc:title>Molecular consequences of SARS-CoV-2 liver tropism</dc:title>
  <dc:type>info:eu-repo/semantics/other</dc:type>
  <dc:type>dataset</dc:type>
</oai_dc:dc>