December 1, 2020 Dataset Open Access

Wanner, Nicola; Andrieux, Geoffroy; Puelles, Victor G

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{"conceptdoi":"10.25592/uhhfdm.8357","conceptrecid":"8357","created":"2022-01-24T18:57:04.634512+00:00","doi":"10.25592/uhhfdm.8358","id":8358,"links":{"badge":"https://www.fdr.uni-hamburg.de/badge/doi/10.25592/uhhfdm.8358.svg","conceptbadge":"https://www.fdr.uni-hamburg.de/badge/doi/10.25592/uhhfdm.8357.svg","conceptdoi":"http://doi.org/10.25592/uhhfdm.8357","doi":"http://doi.org/10.25592/uhhfdm.8358"},"metadata":{"access_right":"open","access_right_category":"success","communities":[{"id":"uhh"}],"creators":[{"affiliation":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany","name":"Wanner, Nicola","orcid":"0000-0002-4886-7020"},{"affiliation":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany","name":"Andrieux, Geoffroy","orcid":"0000-0002-5389-9481"},{"affiliation":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany","name":"Puelles, Victor G","orcid":"0000-0002-7735-5462"}],"description":"<p>Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidney and liver. Previous studies have shown that close to 20% of hospitalized patients with COVID-19 develop liver injury, showing an association to disease severity. Here, we characterized SARS-CoV-2 liver tropism in autopsy samples, based on the expression of cell-entry facilitators in parenchymal cells, clinical polymerase chain reaction (PCR) positivity, subgenomic SARS-CoV-2 identification using RNA sequencing, and viral RNA detection by in situ hybridization. Next, we unraveled the transcriptomic&nbsp; landscape of SARS-CoV-2 liver tropism, revealing significant increases in interferon alpha and gamma signaling and compensatory liver-specific metabolic regulation. While these results reflect changes in tissues from patients with severe SARS-CoV-2 infection, the profound molecular alterations raise questions about the potential long-term consequences of COVID-19 infection. &nbsp;&nbsp;</p>","doi":"10.25592/uhhfdm.8358","keywords":["COVID-19","SARS-CoV-2","liver","transcriptome"],"license":{"id":"CC-BY-4.0"},"publication_date":"2020-12-01","related_identifiers":[{"identifier":"10.25592/uhhfdm.8357","relation":"isVersionOf","scheme":"doi"}],"relations":{"version":[{"count":1,"index":0,"is_last":true,"last_child":{"pid_type":"recid","pid_value":"8358"},"parent":{"pid_type":"recid","pid_value":"8357"}}]},"resource_type":{"title":"Dataset","type":"dataset"},"title":"Molecular consequences of SARS-CoV-2 liver tropism"},"owners":[148],"revision":2,"updated":"2024-02-28T09:47:03.985533+00:00"}